The reference site for Diltiazem

Diltiazem (INN) (/dɪlˈtaɪəzɛm/) is a nondihydropyridine (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia.

WHAT IS Diltiazem?

Diltiazem is used to treat several medical conditions, including hypertension (high blood pressure), angina (chest pain), and even to slow unusually fast heartbeats.

Diltiazem is in a class of drugs called calcium channel blockers. It works by relaxing (widening) your blood vessels (veins and arteries), which in turn makes it easier for your heart to pump and reduces the workload on it.

Some of the brand names that diltiazem is marketed under include Cardizem®, Cartia XT®, Tiazac®, and Tiamate®. 

 

Brand Name(s): Cardizem; Cardizem CD; Cardizem SR; Cartia XT; Dilacor XR; Diltia XT; Tiazac
CAS nº: 42399-41-7
(dil tye’ a zem)

 

Product Info

The sections below will provide you with more specific information and guidelines related to diltiazem and its correct use. Please read them carefully.

FDA Information

In 2004, the U.S. Food and Drug Administration (FDA) approved Cardizem LA® (ditiazem) for the treatment of chronic stable angina.

Cardizem LA® had also been earlier approved for the treatment of high blood pressure or hypertension and is a long acting extended-release formulation of diltiazem HCl.

Why is this medication prescribed?

Diltiazem is used to treat hypertension (high blood pressure), angina (chest pain), and to slow unusually fast heartbeats.

Diltiazem belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body.

By relaxing coronary arteries, diltiazem is useful in treating and preventing chest pain (angina) resulting from coronary artery spasm. The effect of relaxing the muscles lining the arteries of the rest of the body results in a lowering of blood pressure, which reduces the burden on the heart as it pumps blood to the body. So too, reducing heart burden lessens the heart muscle’s demand for oxygen, and further helps to prevent angina in patients with coronary artery disease.

Other uses for this medicine

Diltiazem is also used sometimes to treat Raynaud’s syndrome.

However, before taking this medication, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Diltiazem comes as a tablet and an extended or dual-release (long-acting) capsule to be taken by mouth.

The tablet is usually taken three or four times a day with or without food.

On the other hand, the capsule is usually taken one or two times a day. Remember to swallow the capsules whole and never split, chew, or crush them.

The extended-release capsule (Cardizem SR®, Dilacor XR®, and Diltia XT®) should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.

The extended-release capsule (Tiazac®) may be taken with or without food.

The dual-release capsule (Cardizem CD®) may be taken with food.

Take diltiazem exactly as directed by your doctor. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not stop taking this medication without first talking to your doctor. If you stop taking the medication, your condition could become worse.

What special precautions should I follow?

Before taking diltiazem:

Tell your doctor if you have ever had an allergic reaction to any form of diltiazem in the past, or ever suffered from kidney disease, liver disease, or other diseases of the heart or blood vessels such as sick sinus syndrome, aortic stenosis, congestive heart failure, heart block, low blood pressure, or coronary artery disease.

You may not be able to take diltiazem, or you may require a dosage adjustment or special monitoring during treatment, if you have any of the conditions listed above.

Talk to your doctor about consuming grapefruit or grapefruit juice while you are taking diltiazem. Diltiazem can interact with grapefruit and grapefruit juice and the interaction may have dangerous effects.

Diltiazem is in the FDA pregnancy category C. This means that it is not known whether diltiazem will be harmful to an unborn baby. Do not take diltiazem without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Diltiazem passes into breast milk and may affect a nursing infant. Do not take diltiazem without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Never take a double dose to make up for a missed one.

What side effects can this medication cause?

Possible side effects from using diltiazem are:

abnormally slow heartbeat (more common with Cardizem SR® and Cardizem CD®)
dizziness
fluid retention
flushing (more common with Cardizem SR® and Cardizem CD®)
headache
nausea
rash
weakness

Tell your doctor if any of these symptoms are severe or do not go away:

dizziness or lightheadedness
excessive tiredness
slower heartbeat
upset stomach
loss of appetite
vomiting
diarrhea
constipation
stomach pain
dry mouth
difficulty falling asleep or staying asleep

If you experience any of the following symptoms, call your doctor immediately:

swelling of the face, eyes, lips, tongue, arms, or legs
difficulty breathing or swallowing
fainting
rash
yellowing of the skin or eyes.
fever
increase in frequency or severity of chest pain (angina)

Other side effects than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

dizziness
weakness
chest pain
shortness of breath
fainting
unusually fast or slow heartbeat
coma
slurred speech
confusion

Product Images

Pictures of Diltiazem pills

Below you will find images and specific information on the principal types of diltiazem that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: CARDIZEM®
Strength(s): 30 MG
Imprint: MARION 1771
Manufacturer: BIOVAIL

Name: DILTIAZEM
Strength(s): 30 MG
Imprint: 93 318
Manufacturer: TEVA USA

Name: DILTIAZEM
Strength(s): 30 MG
Imprint: M 23
Manufacturer: MYLAN

Name: CARDIZEM®
Strength(s): 60 MG
Imprint: MARION | 17 72
Manufacturer: BIOVAIL

Name: DILTIAZEM
Strength(s): 60 MG
Imprint: M 45
Manufacturer: MYLAN

Name: DILTIAZEM
Strength(s): 60 MG
Imprint: 93 319
Manufacturer: TEVA USA

Name: DILTIAZEM
Strength(s): 60 mg
Imprint: WATSON 776
Manufacturer: WATSON LABS.

Name: DILTIAZEM
Strength(s): 90 MG
Imprint: 93 320
Manufacturer: TEVA USA

Name: DILTIAZEM
Strength(s): 90 mg
Imprint: M 135
Manufacturer: MYLAN

Name: CARDIZEM®
Strength(s): 90 MG
Imprint: CARDIZEM | 90 MG
Manufacturer: BIOVAIL

Name: DILTIAZEM
Strength(s): 120 MG
Imprint: M525
Manufacturer: MYLAN

Name: DILTIAZEM
Strength(s): 120 MG
Imprint: 92 321
Manufacturer: TEVA USA

Name: DILTIAZEM
Strength(s): 120 MG
Imprint: WATSON 778
Manufacturer: WATSON LABS.

Name: DILTIAZEM
Strength(s): 300 MG
Imprint: R 2579
Manufacturer: ALPHARMA USPD.

Name: DILTIAZEM
Strength(s): 300 MG
Imprint: BVF 300
Manufacturer: TEVA USA

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